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Organ System Integration

Gastrointestinal System Complete Content Map

Integrated coverage of embryology, anatomy, histology, physiology, pathology, and pharmacology. Each module includes core topics, high‑yield subtopics, and clinical correlations for Step 1 mastery.

6
Core domains
70+
Core subtopics
60+
Clinical correlations
🧫 Gastrointestinal Curriculum
Mapped to USMLE Step 1 content outline. Each block below links to a dedicated module with full hierarchical breakdown — core topics, high‑yield details, and clinical correlations.
3.1

Embryology

Foregut, midgut, hindgut; midgut rotation; liver/pancreas development; congenital anomalies (TE fistula, pyloric stenosis, malrotation, Meckel diverticulum, Hirschsprung).

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3.2

Gross Anatomy

Peritoneum, stomach, small/large intestine, liver, biliary system, pancreas, spleen, abdominal vasculature, portosystemic anastomoses.

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3.3

Histology

GI wall layers, regional histology, gastric gland cells, small intestine cell types, liver acinus, pancreas histology.

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3.4

Physiology

Salivary secretion, gastric acid regulation, pancreatic secretion, bile metabolism, GI hormones, digestion/absorption, motility, defecation reflex.

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3.5

Pathology

Esophageal disorders (achalasia, GERD, Barrett, cancer), gastric disorders (PUD, H. pylori, gastric cancer), small intestine (celiac, IBD), colorectal, liver (cirrhosis, HCC), biliary, pancreatic.

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3.6

Pharmacology

Acid‑reducing agents (PPIs, H2 blockers, antacids), antiemetics, laxatives, antidiarrheals, IBD medications (5‑ASA, steroids, immunomodulators, biologics), hepatic encephalopathy treatment.

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