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Foundational Science

Biochemistry Core Disciplines

Complete Step 1 biochemistry content organized into eight major topics. Each module includes core topics, high‑yield subtopics, and clinical correlations. Follow the hierarchical links to master every concept.

8
Major topics
40+
Core subtopics
30+
Clinical correlations
📘 Complete Biochemistry Curriculum
Organised according to the USMLE Step 1 content outline. Each block below links to a dedicated module with full hierarchical breakdown — from core topics to high‑yield details and clinical vignettes.
1.1

Molecular Biology & Genetics

DNA structure & replication, transcription, translation, gene regulation, mutations, and epigenetics. Foundational for understanding inheritance and molecular medicine.

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1.2

Cellular Biology

Cell cycle, apoptosis, signaling pathways, cytoskeleton, organelles. Essential for understanding cancer, immunology, and tissue homeostasis.

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1.3

Carbohydrate Metabolism

Glycolysis, gluconeogenesis, TCA cycle, oxidative phosphorylation, pentose phosphate pathway. Core metabolic pathways with frequent Step 1 emphasis.

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1.4

Lipid Metabolism

Fatty acid oxidation & synthesis, ketogenesis, cholesterol metabolism, lipoproteins, eicosanoids. Key for cardiovascular disease and energy regulation.

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1.5

Amino Acid & Protein Metabolism

Amino acid catabolism, urea cycle, heme synthesis, one‑carbon metabolism, protein folding. Direct links to inborn errors of metabolism.

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1.6

Nucleotide Metabolism

Purine/pyrimidine synthesis & degradation, salvage pathways, nucleotide analogs. Critical for understanding chemotherapy and genetic disorders.

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1.7

Vitamins & Cofactors

Water‑soluble and fat‑soluble vitamins, trace minerals, and their biochemical roles. High‑yield for deficiency syndromes and enzyme function.

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1.8

Nutrition & Metabolic Integration

Fed vs. fasting states, hormonal regulation (insulin, glucagon), tissue‑specific metabolism, metabolic syndrome. Integrates all pathways.

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